Abstract: To investigate the characteristics and corresponding prognostic factors of pulmonary solid adenocarcinomas with mucin component ( SACM ). Methods: Clinical data from 61 SACM patients admitted to our hospital from July 1975 to April 2010 were reviewed. Among these patients, 54 underwent surgery followed by other adjuvant treatments, whereas the other 7 patients received non-surgical therapy. The potential prognostic factors, including gender, age, smoking history, tumor location, tumor size, lymph node metastasis, and pathological tumor-node-metastasis ( p-TNM ) stage, were analyzed. The survival rates were calculated and compared using the Kaplan–Meier method and log-rank test, respectively. Univariate and multivariate factors for survival were analyzed by the Cox proportional hazards regression model. Results: The overall 1-, 3-, and 5-year survival rates were 77.3%, 44.8%, and 25.2%, respectively. The Cox univariate analysis revealed that tumor size ( P < 0.001 ), lymph node metastasis ( P = 0.014 ), metastasis  stage ( M stage ) ( P = 0.013 ), p-TNM stage ( P = 0.006 ), treatment methods ( P < 0.001 ), and surgical techniques ( P = 0.006 ) were prognostic factors. Additionally, tumor size ( P = 0.015 ), lymph node metastasis ( P < 0.001 ), M stage ( P = 0.013 ), and treatment methods were found as independent prognostic factors for SACM. Conclusion: SACM is a rare subtype of lung cancer and shows no specificity in its clinical characteristics. SACM has a high rate of lymph node metastasis and poor prognosis. Tumor size, lymph node metastasis, M stage, and treatment methods were the crucial prognostic factors for SACM. Complete surgical resection should be considered as the main treatment for SACM. High survival rates may be obtained by early diagnosis and optimal treatment.